Description

(S)-2-(((Benzyloxy)Carbonyl)Amino)-2-(Tetrahydro-2H-Pyran-4-Yl)Acetic Acid CAS NO 1098184-12-3 is a high-purity, non-natural amino acid derivative featuring a chiral center and a protected amine group, making it a critical building block for advanced organic synthesis. Its value lies in enabling the precise construction of complex molecules with defined stereochemistry, which is essential for developing bioactive compounds. This intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on producing peptides, protease inhibitors, and other novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel drug candidates, particularly protease inhibitors and enzyme-targeted therapies.
• Peptide Synthesis: Used to incorporate a constrained, cyclic ether-containing amino acid analog into custom peptide sequences for structure-activity relationship (SAR) studies.
• Chemical Biology Research: Serves as a precursor for designing molecular probes and inhibitors to study enzyme function and biological pathways.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective reactions to create enantiomerically pure compounds.
• API Development: Integral in the research and process development stages for new Active Pharmaceutical Ingredients requiring specific stereochemical configurations.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring high-purity chiral intermediates.

Basic Information

Product Name	(S)-2-(((Benzyloxy)Carbonyl)Amino)-2-(Tetrahydro-2H-Pyran-4-Yl)Acetic Acid
CAS No.	1098184-12-3
Molecular Formula	C15H19NO5
Molecular Weight	293.32 g/mol
Synonyms	(S)-2-((((Benzyloxy)carbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid; (S)-2-(N-Cbz-amino)-2-(tetrahydropyran-4-yl)acetic acid; (S)-N-Cbz-2-amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid; Cbz-(S)-Amino(tetrahydro-2H-pyran-4-yl)acetic acid; (S)-2-(Benzyloxycarbonylamino)-2-(tetrahydropyran-4-yl)acetic acid; Z-(S)-Amino(THP-4-yl)acetic acid; (S)-N-[(Benzyloxy)carbonyl]-2-(oxan-4-yl)glycine; (2S)-2-[[(Benzyloxy)carbonyl]amino]-2-(oxan-4-yl)acetic acid
EINECS	Contact for details

Quality Control

Our (S)-2-(((Benzyloxy)Carbonyl)Amino)-2-(Tetrahydro-2H-Pyran-4-Yl)Acetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard pharmacopeial identification tests. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.