Description

Chloro(p-Cymene)[(1R,2R)-(-)-2-Amino-1,2-Diphenylethyl(Methylsulfonylamido)]Ruthenium(II) RuCl(p-Cymene)[(R,R)-MsDPEN] is a highly specialized, chiral ruthenium complex that serves as a premier asymmetric hydrogenation catalyst. Its value lies in enabling the efficient and enantioselective synthesis of key pharmaceutical intermediates and fine chemicals with high optical purity. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance catalysts for complex synthetic transformations.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of ketones, imines, and functionalized olefins in pharmaceutical synthesis.
• Pharmaceutical Intermediate Production: Key for manufacturing chiral active pharmaceutical ingredients (APIs), including β-amino alcohols and other valuable motifs.
• Fine Chemical Synthesis: Used in the production of high-value specialty chemicals requiring precise stereochemical control.
• Academic and Industrial R&D: A critical tool for methodological development in organic synthesis and catalysis research.
• Process Chemistry Optimization: Employed in scaling up enantioselective routes from laboratory to pilot plant and production scale.

Basic Information

Product Name	Chloro(p-Cymene)[(1R,2R)-(-)-2-Amino-1,2-Diphenylethyl(Methylsulfonylamido)]Ruthenium(II)
CAS No.	1097730-63-6
Molecular Formula	C24H29ClN2O2RuS
Molecular Weight	546.08 g/mol
Synonyms	RuCl(p-cymene)[(R,R)-MsDPEN]; (R,R)-Ru-MsDPEN(p-cymene)Cl; [(R,R)-2-Amino-1,2-diphenylethyl(methylsulfonylamido)]chloro(p-cymene)ruthenium(II); Noyori-Ikariya Catalyst Derivative; Asymmetric Hydrogenation Catalyst Ru-MsDPEN; RuCl[(R,R)-MsDPEN](p-cymene); Chiral Ruthenium-Diamine Complex; (1R,2R)-(-)-2-Amino-1,2-diphenylethyl(methylsulfonylamido)chloro(p-cymene)ruthenium
EINECS	Contact for details

Quality Control

Our Chloro(p-Cymene)[(R,R)-MsDPEN]Ruthenium(II) is produced under strict quality management protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by NMR, HPLC, and elemental analysis to verify identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting cGMP-compliant development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cool environment. This compound is moisture-sensitive and easily oxidized; prolonged exposure to air or ambient humidity should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Ruthenium Content	18.0 - 19.0%
Solubility	Soluble in dichloromethane, toluene; slightly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.