Description

2-(1,1-Dioxidotetrahydrothiophen-3-Yl)-1,3-Dioxoisoindoline-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfone and phthalimide functional groups. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and proprietary drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting various disease pathways.
• Protease Inhibitor Research: Used in the development of drug candidates designed to inhibit specific proteases, leveraging its phthalimide core.
• Kinase Inhibitor Scaffold: Serves as a core scaffold or precursor for the development of small molecule kinase inhibitors in oncology research.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme function and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up activities.
• Academic & Industrial R&D: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	2-(1,1-Dioxidotetrahydrothiophen-3-Yl)-1,3-Dioxoisoindoline-5-Carboxylic Acid
CAS No.	1097046-53-1
Molecular Formula	C13H11NO6S
Molecular Weight	309.29 g/mol
Synonyms	5-Carboxy-2-(3-sulfolanyl)isoindoline-1,3-dione; 2-(1,1-Dioxido-3-thiolanyl)-1,3-dioxoisoindoline-5-carboxylic acid; 2-(Tetrahydro-1,1-dioxido-3-thienyl)-1H-isoindole-1,3(2H)-dione-5-carboxylic acid; 2-(1,1-Dioxotetrahydro-3-thienyl)phthalimide-5-carboxylic acid; 1,3-Dioxo-2-(1,1-dioxidotetrahydrothiophen-3-yl)isoindoline-5-carboxylic acid; 1097046-53-1; Sulfolanylphthalimide carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 2-(1,1-Dioxidotetrahydrothiophen-3-Yl)-1,3-Dioxoisoindoline-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.