Description

4-Prolylmorpholine Hydrochloride is a high-purity, non-natural amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel pharmaceutical agents and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, peptide mimetics, and the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetics & Drug Design: Used to construct constrained peptide analogs and scaffolds that mimic natural peptide structures, enhancing metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective synthesis to introduce the proline-morpholine motif into target molecules.
• Chemical Biology & Proteomics: Useful in the design and synthesis of chemical probes, enzyme inhibitors, and tool compounds for studying biological pathways.
• Agrochemical Research: Potential intermediate in the discovery of new herbicides or fungicides with novel modes of action.

Basic Information

Product Name	4-Prolylmorpholine Hydrochloride
CAS No.	1096446-01-3
Molecular Formula	C9H17ClN2O2
Molecular Weight	220.70 g/mol
Synonyms	4-(Morpholin-4-yl)-L-proline hydrochloride; L-Proline, 4-(4-morpholinyl)-, hydrochloride (1:1); 4-Morpholinoproline HCl; (S)-4-(Morpholin-4-yl)pyrrolidine-2-carboxylic acid hydrochloride; 4-Prolylmorpholine HCl; 4-Prolylmorpholine monohydrochloride; 1096446-01-3
EINECS	Contact for details

Quality Control

Our 4-Prolylmorpholine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.