Description

cis-3-Methylcyclobutanamine Hydrochloride is a high-purity, synthetically derived amine salt with the CAS number 1093951-55-3, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized cyclobutane scaffold essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, process development, and the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, leveraging the steric and electronic properties of the methylcyclobutane ring.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Chemical Biology Probe: Employed in the synthesis of molecular probes to study enzyme mechanisms and protein-ligand interactions due to its constrained geometry.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing polymers with unique thermal and mechanical properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including ring-opening and functionalization reactions.

Basic Information

Product Name	cis-3-Methylcyclobutanamine Hydrochloride
CAS No.	1093951-55-3
Molecular Formula	C5H12ClN
Molecular Weight	121.61 g/mol
Synonyms	cis-3-Methylcyclobutan-1-amine hydrochloride; (1s,3s)-3-Methylcyclobutan-1-amine hydrochloride; 3-Methylcyclobutanamine hydrochloride, cis-; 1-Amino-3-methylcyclobutane hydrochloride, cis-; 3-Methylcyclobutylamine hydrochloride; Aminomethylcyclopropane hydrochloride (related); Cyclobutanamine, 3-methyl-, hydrochloride, cis-
EINECS	Contact for details

Quality Control

Every batch of cis-3-Methylcyclobutanamine Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for assay, chiral purity, and related substances as determined by advanced chromatographic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.