Description

2-Ethoxy-1-Fluoro-4-Nitrobenzene is a specialized aromatic nitro compound featuring both ethoxy and fluoro substituents, making it a valuable building block in advanced organic synthesis. Its unique structure provides a versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This high-purity intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and material science industries seeking reliable and consistent quality for their critical synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those requiring a fluorinated aromatic core for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides, where the nitro and fluoro groups contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex dyes and pigments, leveraging the nitro group as a chromophore and the ethoxy group for solubility modification.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl structures common in many functional molecules.

Basic Information

Product Name	2-Ethoxy-1-Fluoro-4-Nitrobenzene
CAS No.	1093656-34-8
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	1-Ethoxy-2-fluoro-4-nitrobenzene; 2-Fluoro-4-nitroanisole; 4-Nitro-2-fluoroanisole; 2-Fluoro-1-ethoxy-4-nitrobenzene; 1-Fluoro-2-ethoxy-4-nitrobenzene; 4-Nitro-2-fluoro-1-ethoxybenzene; Benzene, 1-ethoxy-2-fluoro-4-nitro-; 2-Fluoro-4-nitro-1-ethoxybenzene
EINECS	Contact for details

Quality Control

Every batch of 2-Ethoxy-1-Fluoro-4-Nitrobenzene is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure compliance with exacting purity standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its sensitivity, the container should be kept tightly sealed under an inert atmosphere to prevent oxidation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.