Description

(4-(1,2,4,5-Tetrazin-3-Yl)Phenyl)Methanamine Hcl is a high-purity, functionalized tetrazine derivative supplied as its hydrochloride salt. This compound is a critical building block and linker in advanced bioconjugation and materials science, enabling precise and stable cross-linking via bioorthogonal inverse electron demand Diels-Alder (IEDDA) reactions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the synthesis of novel polymers and smart materials who require reliable, high-quality chemical intermediates. The product is identified by CAS No. 1092689-33-2.

Application

• Bioconjugation Reagent: A key component for site-specific labeling of proteins, antibodies, and oligonucleotides in diagnostic and therapeutic development.
• Chemical Biology Probes: Used to synthesize probes for live-cell imaging and target identification via bioorthogonal chemistry.
• ADC (Antibody-Drug Conjugate) Linker Chemistry: Facilitates the stable attachment of cytotoxic payloads to targeting antibodies.
• Materials Science & Polymer Chemistry: Serves as a functional monomer or cross-linker for creating stimuli-responsive hydrogels and advanced polymeric networks.
• Precision Medicine Research: Enables the development of targeted drug delivery systems and personalized therapeutic agents.
• Radiopharmaceuticals: Potential use in chelator-free radiolabeling strategies for PET imaging agents.

Basic Information

Product Name	(4-(1,2,4,5-Tetrazin-3-Yl)Phenyl)Methanamine Hydrochloride
CAS No.	1092689-33-2
Molecular Formula	C9H10ClN5
Molecular Weight	223.66 g/mol
Synonyms	1-(4-Aminomethylphenyl)-1,2,4,5-tetrazine hydrochloride; 4-(1,2,4,5-Tetrazin-3-yl)benzylamine hydrochloride; TCO-Tetrazine Amine HCl; (4-(Tetrazin-3-yl)phenyl)methanamine hydrochloride; 3-(4-(Aminomethyl)phenyl)-1,2,4,5-tetrazine HCl; BCN-Tetrazine Amine Hydrochloride; Tetrazine-PEG4-Amine HCl (related derivative); Amine-PEG4-Tetrazine HCl (related derivative)
EINECS	Contact for details

Quality Control

Our (4-(1,2,4,5-Tetrazin-3-Yl)Phenyl)Methanamine Hcl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and NMR, are validated to provide reliable specifications for our customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.