Description

2-Chloroquinoline-5-Carboxylic Acid is a versatile and high-value halogenated quinoline derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a carboxylic acid and a chlorine substituent on the quinoline scaffold, makes it an essential intermediate for constructing complex molecules with targeted functionalities. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of quinoline-based drug candidates, particularly for antimicrobial, anticancer, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, leveraging the bioactivity of the quinoline core.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the development of organic semiconductors, light-emitting materials, and metal-organic frameworks (MOFs) due to its rigid, planar structure and functional handles.
• Chemical Biology Probes: Utilized to synthesize fluorescent tags or molecular probes for studying biological processes and enzyme inhibition.

Basic Information

Product Name	2-Chloroquinoline-5-Carboxylic Acid
CAS No.	1092287-30-3
Molecular Formula	C10H6ClNO2
Molecular Weight	207.61 g/mol
Synonyms	5-Quinolinecarboxylic acid, 2-chloro-; 2-Chloro-5-quinolinecarboxylic acid; 2-Chloroquinoline-5-carboxylic acid; Quinoline-5-carboxylic acid, 2-chloro derivative; 2-Cl-5-QCA
EINECS	Contact for details

Quality Control

Our 2-Chloroquinoline-5-Carboxylic Acid is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up processes. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.