Description

22-Amino-5,8,11,14,17,20-Hexaoxa-2-Azadocosanoic Acid 1,1-Dimethylethyl Ester is a specialized, high-purity PEG-based linker molecule featuring a terminal amino group and a protected carboxylic acid. This compound is engineered to provide a reliable and versatile building block for bioconjugation and advanced materials synthesis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors for creating stable, water-soluble conjugates of peptides, proteins, and other bioactive molecules.

Application

• Bioconjugation Linker: For coupling peptides, proteins, or antibodies to drugs, dyes, or solid surfaces in ADC (Antibody-Drug Conjugate) development and diagnostic assay fabrication.
• PEGylation Reagent: Acts as a functionalized PEG spacer to improve the solubility, stability, and pharmacokinetic profiles of therapeutic biomolecules.
• Polymer & Dendrimer Synthesis: Serves as a key monomer or branching unit for constructing functionalized, biocompatible polymers and dendritic structures.
• Surface Functionalization: Used to introduce amine-reactive groups onto nanoparticles, quantum dots, or biosensor chips for subsequent biomolecule attachment.
• Cross-linking Agent: Facilitates the formation of stable bridges between molecules in hydrogel formation or biomaterial engineering.
• Intermediate for Prodrugs: Employed in the synthesis of prodrugs where a cleavable PEG linker is required for targeted drug release.

Basic Information

Product Name	22-Amino-5,8,11,14,17,20-Hexaoxa-2-Azadocosanoic Acid 1,1-Dimethylethyl Ester
CAS No.	1091627-77-8
Molecular Formula	C₂₃H₄₆N₂O₈
Molecular Weight	478.63 g/mol
Synonyms	Boc-NH-PEG6-CH2CH2COOH; t-Butyl 22-amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoate; Boc-Amino-PEG6-Acid; 2-{2-[2-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}acetic Acid; Amino-PEG6-t-butyl ester; Boc-N-amido-PEG6-acid; tert-Butyl 19-{2-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-19-oxo-3,6,9,12,15-pentaoxa-18-azanonadecanoate
EINECS	Contact for details

Quality Control

Every batch of 22-Amino-5,8,11,14,17,20-Hexaoxa-2-Azadocosanoic Acid 1,1-Dimethylethyl Ester is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and cGMP-grade material production. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.