Description

tert-Butyl 7-Carboxy-4-Oxo-Spiro[Chroman-2,4-Piperidine]-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and chroman scaffold. This compound is of significant value for its role as a key building block in the synthesis of novel, small-molecule drug candidates, particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries via further functionalization of the carboxylic acid and piperidine nitrogen, enabling structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Used in the development and optimization of synthetic routes for potential drug candidates during the transition from laboratory to pilot and commercial scale.
• Protease Inhibitor Synthesis: The spirocyclic chroman-piperidine core is a privileged structure found in inhibitors for various enzymes, making this intermediate relevant for targeted drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to partners requiring a reliable source of this specific, high-quality intermediate for their proprietary synthesis projects.

Basic Information

Product Name	tert-Butyl 7-Carboxy-4-Oxo-Spiro[Chroman-2,4-Piperidine]-1-Carboxylate
CAS No.	1086398-20-0
Molecular Formula	C19H23NO5
Molecular Weight	345.39 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-7-carboxy-4-oxospiro[chroman-2,4'-piperidine]; 1-Boc-7-carboxy-4-oxospiro[chroman-2,4'-piperidine]; tert-Butyl 7-carboxy-4-oxospiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylate; 4-Oxospiro[chroman-2,4'-piperidine]-1'-carboxylic acid, 7-carboxy-, 1,1-dimethylethyl ester; Spiro[chroman-2,4'-piperidine]-1'-carboxylic acid, 7-carboxy-4-oxo-, 1,1-dimethylethyl ester; 1086398-20-0; Boc-Protected 7-Carboxyspirochromone Piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Carboxy-4-Oxo-Spiro[Chroman-2,4-Piperidine]-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.