Description

8-Chloro-1,2,3,4-tetrahydro-[1,7]naphthyridine is a high-purity, synthetically valuable heterocyclic building block with the CAS number 1086392-56-4. This compound is a critical intermediate in modern pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and fine chemical manufacturers engaged in medicinal chemistry, especially for projects targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key scaffold for the synthesis of novel drug candidates in medicinal chemistry programs.
• Chemical Research & Development: Used as a versatile building block for constructing complex heterocyclic libraries for high-throughput screening.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core structural unit in the multi-step synthesis of potential therapeutic agents.
• Contract Research Organization (CRO) & Contract Development and Manufacturing Organization (CDMO) Projects: Supplied for custom synthesis and process development for client-specific molecules.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) and novel synthetic methodologies.
• Pre-clinical Development: Employed in the production of compounds for pharmacological and toxicological evaluation.

Basic Information

Item	Details
Product Name	8-Chloro-1,2,3,4-tetrahydro-[1,7]naphthyridine
CAS No.	1086392-56-4
Molecular Formula	C8H9ClN2
Molecular Weight	168.62 g/mol
Synonyms	8-Chloro-1,2,3,4-tetrahydro-1,7-naphthyridine; 1,2,3,4-Tetrahydro-8-chloro-[1,7]naphthyridine; 8-Chloro-5,6,7,8-tetrahydro-[1,7]naphthyridine; 1086392-56-4; 8-Chloro-1,2,3,4-tetrahydro-1,7-naphthyridine; Tetrahydro-8-chloro[1,7]naphthyridine
EINECS	Contact for details

Quality Control

Our 8-Chloro-1,2,3,4-tetrahydro-[1,7]naphthyridine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality systems are designed to support cGMP requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.