Description

(1R)-1-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Ethylamine is a high-purity chiral amine building block of significant importance in modern pharmaceutical and agrochemical research. Its core value lies in its unique stereochemistry and trifluoromethyl-substituted aromatic ring, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical industry who are developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring potent and selective small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Development: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance lipophilicity and membrane permeability.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science Research: Investigated as a monomer or functional additive for specialty polymers and advanced materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the development of molecular probes and diagnostic agents for biochemical and pharmacological studies.

Basic Information

Product Name	(1R)-1-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Ethylamine
CAS No.	1079656-95-3
Molecular Formula	C9H9F4N
Molecular Weight	207.17 g/mol
Synonyms	(R)-1-(4-Fluoro-3-(trifluoromethyl)phenyl)ethan-1-amine; (R)-1-[4-Fluoro-3-(trifluoromethyl)phenyl]ethylamine; (1R)-1-[4-Fluoro-3-(trifluoromethyl)phenyl]ethanamine; (R)-α-Methyl-4-fluoro-3-(trifluoromethyl)benzylamine; (R)-1-(4-Fluoro-3-trifluoromethyl-phenyl)-ethylamine; (R)-4-Fluoro-α-methyl-3-(trifluoromethyl)benzenemethanamine
EINECS	Contact for details

Quality Control

Our (1R)-1-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Ethylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.