Description

(S,E)-n-(Cyclopropylmethylene)-2-Methylpropane-2-Sulfinamide CAS NO 1075715-48-8 is a high-purity chiral sulfinamide building block, a critical intermediate in modern asymmetric synthesis. Its value lies in its ability to act as a highly effective chiral auxiliary or ligand, enabling the stereoselective construction of complex molecules with high enantiomeric purity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of small molecule drugs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Asymmetric Catalysis: Used as a precursor for chiral ligands or catalysts in transition metal-catalyzed reactions, such as asymmetric hydrogenations, cross-couplings, and additions.
• Agrochemical Synthesis: Employed in the research and production of enantiomerically pure herbicides, fungicides, and insecticides, where specific stereochemistry is often crucial for activity and environmental safety.
• Methodology Development: Serves as a standard or test substrate in academic and industrial laboratories for developing new asymmetric synthetic methodologies.
• Fine Chemical Production: Utilized in the multi-step synthesis of other high-value, complex chiral fine chemicals and specialty materials.

Basic Information

Product Name	(S,E)-n-(Cyclopropylmethylene)-2-Methylpropane-2-Sulfinamide
CAS No.	1075715-48-8
Molecular Formula	C8H15NOS
Molecular Weight	173.28 g/mol
Synonyms	(S,E)-N-(Cyclopropylmethylene)-2-methylpropane-2-sulfinamide; (S,E)-N-(1-Cyclopropylethylidene)-2-methylpropane-2-sulfinamide; (S,E)-tert-Butanesulfinamide Cyclopropylmethylidene Derivative; (S,E)-N-(Cyclopropylmethylidene)-tert-butanesulfinamide; (S,E)-N-[(E)-Cyclopropylmethylene]-2-methylpropane-2-sulfinamide; (S,E)-tert-Butylsulfinyl Imine (Cyclopropyl); Chiral Sulfinamide Auxiliary CAS 1075715-48-8
EINECS	Contact for details

Quality Control

Our (S,E)-n-(Cyclopropylmethylene)-2-Methylpropane-2-Sulfinamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC, NMR, and GC/MS, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. A detailed Certificate of Analysis (COA) providing full specification data is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can compromise product integrity. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.