Description

2-Propanesulfinamide, n-[1-(2-Fluoro-5-Nitrophenyl)Ethylidene]-2-Methyl-, [N(E),S(R)]- is a high-purity chiral sulfinamide building block of significant importance in modern asymmetric synthesis. Its precise stereochemistry makes it a critical intermediate for constructing complex molecules with defined three-dimensional structures. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs) and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral auxiliary or precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Asymmetric Catalysis: Used as a ligand or catalyst component in enantioselective reactions to produce single-isomer compounds.
• Agrochemical Synthesis: Employed in the research and development of advanced, stereochemically pure pesticides and herbicides.
• Academic & Industrial Research: Serves as a valuable tool compound for methodological development in organic and medicinal chemistry laboratories.
• Fine Chemical Production: Integral to the multi-step synthesis of complex, high-value specialty chemicals requiring specific chiral centers.

Basic Information

Product Name	2-Propanesulfinamide, n-[1-(2-Fluoro-5-Nitrophenyl)Ethylidene]-2-Methyl-, [N(E),S(R)]-
CAS No.	1075230-62-4
Molecular Formula	C12H15FN2O3S
Molecular Weight	286.32 g/mol
Synonyms	(R)-2-Methyl-N-[(E)-1-(2-fluoro-5-nitrophenyl)ethylidene]propane-2-sulfinamide; N-[(1E)-1-(2-Fluoro-5-nitrophenyl)ethylidene]-2-methylpropane-2-sulfinamide, (2R)-; (R)-tert-Butanesulfinamide derivative of 2'-fluoro-5'-nitroacetophenone; Chiral Sulfinamide Auxiliary 1075230-62-4; (R)-N-(1-(2-Fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide; (R)-2-Methyl-2-propanesulfinamide, N-[1-(2-fluoro-5-nitrophenyl)ethylidene]-; Fluoronitrophenyl Ethylidene Sulfinamide
EINECS	Contact for details

Quality Control

Our 2-Propanesulfinamide, n-[1-(2-Fluoro-5-Nitrophenyl)Ethylidene]-2-Methyl-, [N(E),S(R)]- is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. Our rigorous quality testing ensures compliance with the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.