Description

(S)-2-(4-Fluorophenyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and intermediate of significant importance in modern synthetic chemistry. Its value lies in its defined stereochemistry and functionalized pyrrolidine core, which is a privileged scaffold in medicinal chemistry. This compound is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapeutic areas.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Asymmetric Synthesis: Employed as a chiral ligand or auxiliary in catalytic asymmetric reactions to induce enantioselectivity.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and library synthesis to explore new bioactive molecules.
• API Development: Serves as a critical building block in the route scouting and process development for new Active Pharmaceutical Ingredients.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological targets and pathways.
• Fine Chemical Production: Intermediate for the manufacture of specialty chemicals requiring a fluorinated pyrrolidine motif.

Basic Information

Product Name	(S)-2-(4-Fluorophenyl)Pyrrolidine Hydrochloride
CAS No.	1073556-40-7
Molecular Formula	C10H12FN•HCl
Molecular Weight	201.67 g/mol (Free base: 165.21 g/mol)
Synonyms	(S)-2-(4-Fluorophenyl)pyrrolidine hydrochloride; (S)-2-(p-Fluorophenyl)pyrrolidine HCl; (2S)-2-(4-Fluorophenyl)pyrrolidine hydrochloride; (S)-(-)-2-(4-Fluorophenyl)pyrrolidine hydrochloride; 4-Fluoro-α-[(2S)-2-pyrrolidinyl]benzenemethanamine hydrochloride; (S)-2-(4-Fluorophenyl)-1-azacyclopentane hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2-(4-Fluorophenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.