Description

8-(Trifluoromethoxy)Quinolin-5-Ylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, specifically in the Suzuki-Miyaura cross-coupling reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, catalyst development, and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing the quinoline scaffold with trifluoromethoxy modifications.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage its unique halogenated quinoline structure.
• Material Science: Serves as a building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura cross-coupling to introduce the quinolin-5-yl moiety into biaryl systems under mild conditions.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for transition metal catalysis and organoboron reagents.
• Chemical Biology Probes: Acts as a synthetic handle for creating fluorescent probes or activity-based protein profiling agents targeting specific biological pathways.

Basic Information

Item	Details
Product Name	8-(Trifluoromethoxy)Quinolin-5-Ylboronic Acid
CAS No.	1072951-46-2
Molecular Formula	C₁₀H₇BF₃NO₃
Molecular Weight	257.97 g/mol
Synonyms	5-Quinolineboronic acid, 8-(trifluoromethoxy)-; (8-(Trifluoromethoxy)quinolin-5-yl)boronic acid; 8-Trifluoromethoxyquinoline-5-boronic acid; Quinolin-5-ylboronic acid, 8-(trifluoromethoxy)-; Boronic acid, B-[8-(trifluoromethoxy)-5-quinolinyl]-
EINECS	Contact for details

Quality Control

Every batch of 8-(Trifluoromethoxy)Quinolin-5-Ylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.