Description

Ethyl 8-Bromo-4-Hydroxy-6-(Trifluoromethoxy)Quinoline-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS number 1072944-81-0. This compound is a critical building block in modern medicinal chemistry, valued for its unique quinoline scaffold functionalized with bromo, hydroxy, and trifluoromethoxy groups, which are key for modulating biological activity and pharmacokinetic properties. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and anti-infective research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new active pharmaceutical ingredients (APIs).
• Organic Synthesis Building Block: Serves as a versatile substrate for further functionalization via cross-coupling reactions, leveraging the reactive bromo substituent.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.
• Material Science: Investigated for the creation of specialty chemicals and functional materials due to its fluorinated aromatic structure.

Basic Information

Product Name	Ethyl 8-Bromo-4-Hydroxy-6-(Trifluoromethoxy)Quinoline-3-Carboxylate
CAS No.	1072944-81-0
Molecular Formula	C₁₃H₉BrF₃NO₄
Molecular Weight	380.12 g/mol
Synonyms	8-Bromo-4-hydroxy-6-(trifluoromethoxy)quinoline-3-carboxylic acid ethyl ester; Ethyl 8-bromo-4-hydroxy-6-(trifluoromethoxy)-3-quinolinecarboxylate; 3-Quinolinecarboxylic acid, 8-bromo-4-hydroxy-6-(trifluoromethoxy)-, ethyl ester; 1072944-81-0; 8-Bromo-4-hydroxy-6-trifluoromethoxy-quinoline-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 8-Bromo-4-Hydroxy-6-(Trifluoromethoxy)Quinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO standards ensures reliable supply for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.