Description

Methyl 8-Bromo-4-Hydroxy-5-(Trifluoromethyl)Quinoline-2-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific quinoline-based pharmacophores into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting infectious diseases, oncology, and central nervous system disorders.
• Agrochemical Research: Serves as a critical building block for developing new generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Used in the research and development of advanced organic electronic materials, such as OLEDs and sensors, due to its quinoline core.
• Chemical Biology: Employed as a molecular probe or a tag in biochemical assays and diagnostic tool development.
• Academic & Contract Research: Essential for synthetic methodology research and for contract research organizations (CROs) serving the life sciences sector.
• Fluorinated Compound Synthesis: The trifluoromethyl group makes it a valuable synthon for introducing fluorine atoms to modulate the bioavailability and metabolic stability of target compounds.

Basic Information

Product Name	Methyl 8-Bromo-4-Hydroxy-5-(Trifluoromethyl)Quinoline-2-Carboxylate
CAS No.	1072944-77-4
Molecular Formula	C₁₂H₇BrF₃NO₃
Molecular Weight	350.09 g/mol
Synonyms	8-Bromo-4-hydroxy-5-(trifluoromethyl)quinoline-2-carboxylic acid methyl ester; Methyl 8-bromo-4-hydroxy-5-(trifluoromethyl)-2-quinolinecarboxylate; 2-Quinolinecarboxylic acid, 8-bromo-4-hydroxy-5-(trifluoromethyl)-, methyl ester; 1072944-77-4; 8-Bromo-4-hydroxy-5-trifluoromethylquinoline-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 8-Bromo-4-Hydroxy-5-(Trifluoromethyl)Quinoline-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for your development and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.