Description

8-(Trifluoromethoxy)Quinolin-5-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinoline scaffold substituted with a trifluoromethoxy group and an amine functionality. This compound is of significant commercial interest for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular frameworks. Research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries utilize this building block to develop new compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for oncology, CNS, and anti-infective therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the biological activity of the quinoline core.
• Material Science: Serves as a precursor for functionalized organic materials, including ligands for catalysis and components for organic electronics.
• Chemical Synthesis: Employed in organic chemistry research for constructing complex heterocyclic compounds and fluorinated molecules.
• Bioconjugation & Probe Development: The amine group allows for conjugation, making it useful in creating fluorescent probes or biochemical tools.

Basic Information

Product Name	8-(Trifluoromethoxy)Quinolin-5-Amine
CAS No.	1072944-53-6
Molecular Formula	C10H7F3N2O
Molecular Weight	228.17 g/mol
Synonyms	5-Amino-8-(trifluoromethoxy)quinoline; 8-(Trifluoromethoxy)-5-quinolinamine; Quinolin-5-amine, 8-(trifluoromethoxy)-; 8-Trifluoromethoxyquinolin-5-amine; 5-Amino-8-trifluoromethoxyquinoline; 8-(Trifluoromethoxy)-5-aminoquinoline
EINECS	Contact for details

Quality Control

Our 8-(Trifluoromethoxy)Quinolin-5-Amine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.