Description

Fmoc-3-Amino-2-Methylbenzoic Acid CAS NO 1072901-47-3 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of a modified anthranilic acid moiety into peptide chains, enabling the research and development of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on peptide-based drug discovery and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated synthesis of custom peptides.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Chemical Biology Probes: Incorporation into peptides designed as tools for studying protein-protein interactions, enzyme activity, and cellular signaling pathways.
• Combinatorial Chemistry: A key component in libraries for high-throughput screening to identify new lead compounds with potential biological activity.
• Bioconjugation: The carboxylic acid group allows for further functionalization and conjugation to other molecules, carriers, or surfaces.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic synthesis, peptide chemistry, and medicinal chemistry.

Basic Information

Product Name	Fmoc-3-Amino-2-Methylbenzoic Acid
CAS No.	1072901-47-3
Molecular Formula	C23H19NO4
Molecular Weight	373.40 g/mol
Synonyms	Fmoc-3-Amino-2-methylbenzoic acid; 2-Methyl-3-[(9H-fluoren-9-ylmethoxy)carbonylamino]benzoic acid; 3-[(Fmoc)amino]-2-methylbenzoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methylanthranilic acid; Fmoc-2-Me-3-Abz-OH; Fmoc-3-Abz(2-Me)-OH; N-Fmoc-3-amino-2-methylbenzoic acid; N3-Fmoc-2-methylisophthalamic acid
EINECS	Contact for details

Quality Control

Our Fmoc-3-Amino-2-Methylbenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.