Description

4-Bromo-7-Fluoro-2-Methylquinoline is a high-purity, halogenated quinoline derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular scaffold, which enables the introduction of both bromine and fluorine substituents to modulate the electronic and steric properties of target molecules. It is primarily sought after by pharmaceutical and agrochemical R&D laboratories for the development of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new therapeutic agents, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule drugs.
• Agrochemical Synthesis: Used as a precursor in the creation of advanced pesticides, herbicides, and fungicides, leveraging the bioactivity of the quinoline core.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Serves as a scaffold for developing fluorescent tags or molecular probes to study biological processes.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Library Synthesis for High-Throughput Screening: Used in combinatorial chemistry to generate diverse compound libraries for biological activity screening.

Basic Information

Product Name	4-Bromo-7-Fluoro-2-Methylquinoline
CAS No.	1070879-48-9
Molecular Formula	C₁₀H₇BrFN
Molecular Weight	240.08 g/mol
Synonyms	7-Fluoro-4-bromo-2-methylquinoline; 2-Methyl-4-bromo-7-fluoroquinoline; 4-Bromo-7-fluoro-2-methylquinoline; Quinoline, 4-bromo-7-fluoro-2-methyl-; 1070879-48-9
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-7-Fluoro-2-Methylquinoline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.