Description

4-Bromo-6-(Trifluoromethyl)Quinoline is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a bromine substituent for cross-coupling reactions and a trifluoromethyl group, which imparts desirable physicochemical properties to target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications requiring enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used to construct novel herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental stability.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl and heteroaryl structures.
• Fluorine Chemistry: Acts as a valuable scaffold for introducing fluorine-containing motifs into molecules for drug discovery and development.
• Chemical Biology: Utilized as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.

Basic Information

Product Name	4-Bromo-6-(Trifluoromethyl)Quinoline
CAS No.	1070879-32-1
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	4-Bromo-6-(trifluoromethyl)quinoline; 6-(Trifluoromethyl)-4-bromoquinoline; Quinoline, 4-bromo-6-(trifluoromethyl)-; 4-Bromo-6-trifluoromethylquinoline; 4-Bromo-6-(trifluoromethyl)chinolin; 4-Brom-6-(trifluormethyl)chinolin
EINECS	Contact for details

Quality Control

Our 4-Bromo-6-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.