Description

2-Iodo-2',4',6'-Triisopropyl-3,6-Dimethoxy-1,1'-Biphenyl is a highly functionalized biphenyl derivative, specifically designed as a sophisticated ligand precursor and a key intermediate in advanced organic synthesis. Its value lies in its sterically hindered, electron-rich structure, which is crucial for modulating the reactivity and selectivity of transition metal catalysts in challenging cross-coupling reactions. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries who require high-purity, structurally complex building blocks for creating novel molecules.

Application

• Ligand Synthesis: A critical precursor for the preparation of specialized phosphine or N-heterocyclic carbene (NHC) ligands used in palladium and nickel-catalyzed reactions.
• Pharmaceutical Intermediates: Serves as a key building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Catalyst Development: Used in research to develop and optimize new homogeneous catalysts for C-C and C-X bond formation under mild conditions.
• Agrochemical Research: Employed in the synthesis of novel, high-performance crop protection agents with specific modes of action.
• Material Science: Acts as a monomer or functional unit in the creation of organic electronic materials, such as those for OLEDs or conductive polymers.
• Methodology Development: A valuable substrate for academic and industrial research in developing new synthetic methodologies, especially involving sterically demanding systems.

Basic Information

Product Name	2-Iodo-2',4',6'-Triisopropyl-3,6-Dimethoxy-1,1'-Biphenyl
CAS No.	1070663-76-1
Molecular Formula	C26H37IO2
Molecular Weight	508.48 g/mol
Synonyms	2-Iodo-2',4',6'-triisopropyl-3,6-dimethoxybiphenyl; 2',4',6'-Triisopropyl-3,6-dimethoxy-2-iodobiphenyl; 1,1'-Biphenyl, 2-iodo-2',4',6'-triisopropyl-3,6-dimethoxy-; Biphenyl-based iodoarene; Sterically hindered iodoarene; SPhos-type ligand precursor; Buchwald ligand intermediate
EINECS	Contact for details

Quality Control

Every batch of 2-Iodo-2',4',6'-Triisopropyl-3,6-Dimethoxy-1,1'-Biphenyl is manufactured and analyzed under strict quality management protocols to ensure consistency and purity for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.