Description

trans-1-(tert-Butoxycarbonyl)-3-Phenylpiperidine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold with both Boc-protected amine and carboxylic acid functional groups. This compound is critical for the synthesis of complex molecules, offering precise stereochemistry and functional group compatibility for medicinal chemistry and process development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile piperidine core.
• Process Chemistry & Scale-up: Serves as a critical starting material or intermediate in the development of scalable GMP manufacturing routes for APIs.
• Peptidomimetic Synthesis: Employed in the construction of peptide analogs and conformationally constrained scaffolds.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for biological target validation.
• Custom Synthesis: A foundational substrate for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	trans-1-(tert-Butoxycarbonyl)-3-Phenylpiperidine-4-Carboxylic Acid
CAS No.	1068522-17-7
Molecular Formula	C17H23NO4
Molecular Weight	305.37 g/mol
Synonyms	trans-1-Boc-3-phenylpiperidine-4-carboxylic acid; 1-(tert-Butoxycarbonyl)-3-phenyl-4-piperidinecarboxylic acid (trans); 3-Phenyl-1-[(2-methyl-2-propanyl)oxycarbonyl]-4-piperidinecarboxylic acid (trans); 1-N-Boc-3-phenylisonipecotic acid (trans); trans-3-Phenyl-1-Boc-piperidine-4-carboxylic acid; trans-4-Carboxy-3-phenyl-1-piperidinecarboxylic acid tert-butyl ester; BOC-3-Phenyl-4-piperidinecarboxylic Acid (trans); trans-1-Boc-3-phenyl-4-piperidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our trans-1-(tert-Butoxycarbonyl)-3-Phenylpiperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if frequent opening is anticipated. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.