Description

tert-Butyl 7-Bromo-2-oxoquinoline-1(2H)-carboxylate is a high-purity, protected heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of complex pharmaceutical molecules, particularly in medicinal chemistry research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel quinoline-based scaffolds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting kinase inhibition or other therapeutic pathways.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and the generation of compound libraries for high-throughput screening.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that utilize the quinoline core structure.
• Material Science Precursor: Employed in the synthesis of organic ligands for metal-organic frameworks (MOFs) or functional materials requiring specific brominated quinoline motifs.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in complex heterocycles.

Basic Information

Product Name	tert-Butyl 7-Bromo-2-oxoquinoline-1(2H)-carboxylate
CAS No.	1068437-26-2
Molecular Formula	C₁₄H₁₄BrNO₃
Molecular Weight	324.17 g/mol
Synonyms	1-Boc-7-bromo-2-hydroxyquinoline; 7-Bromo-1,2-dihydro-2-oxoquinoline-1-carboxylic acid tert-butyl ester; 7-Bromo-2-oxo-1,2-dihydroquinoline-1-carboxylic acid tert-butyl ester; tert-Butyl 7-bromo-2-oxo-1,2-dihydroquinoline-1-carboxylate; 1-(tert-Butoxycarbonyl)-7-bromo-2(1H)-quinolinone; 7-Bromo-1-(tert-butoxycarbonyl)quinolin-2(1H)-one; 7-Bromoquinolin-2(1H)-one-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Bromo-2-oxoquinoline-1(2H)-carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.