Description

2-(2-Bromo-Pyridin-3-Yloxy)-Pyrazine is a high-purity (98+%) brominated heterocyclic building block with the molecular formula C9H6BrN3O and a molecular weight of 252.07. This compound is a critical intermediate in modern pharmaceutical and agrochemical research, valued for its unique pyridine-pyrazine ether structure that enables the synthesis of complex molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional materials.

Application

This specialized brominated intermediate is designed for advanced synthetic chemistry applications, including:

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold for bioactivity.
• Material Science: Serves as a precursor for creating functional organic materials, such as ligands for catalysts or components in organic electronics.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form new carbon-carbon bonds.
• Medicinal Chemistry & SAR Studies: Enables the rapid exploration of structure-activity relationships (SAR) by introducing diverse substituents at the reactive bromine site.
• Chemical Biology Probes: Used to synthesize molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-(2-Bromo-Pyridin-3-Yloxy)-Pyrazine
CAS No.	1065484-64-1
Molecular Formula	C9H6BrN3O
Molecular Weight	252.07 g/mol
Synonyms	2-(2-Bromopyridin-3-yloxy)pyrazine; 3-((Pyrazin-2-yl)oxy)-2-bromopyridine; Pyrazine, 2-[(2-bromo-3-pyridinyl)oxy]-; 2-Bromo-3-(pyrazin-2-yloxy)pyridine; 1065484-64-1
EINECS	Contact for details

Quality Control

Our production of 2-(2-Bromo-Pyridin-3-Yloxy)-Pyrazine adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical research and development. Each lot is manufactured and analyzed under a controlled quality management system. Certificates of Analysis (COA) are provided, detailing purity, identity, and impurity profiles as confirmed by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.