Description

6-tert-Butyl-4-Hydroxy- Quinoline-3-Carboxylic Acid is a high-purity, functionalized quinoline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and specialty materials, where its unique sterically hindered phenolic and carboxylic acid functionalities enable precise molecular design. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to create novel active compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobial compounds.
• Agrochemical Synthesis: Used in the development of advanced pesticides, herbicides, and fungicides, where the quinoline core contributes to biological activity.
• Ligand and Catalyst Development: Serves as a chelating agent or precursor for metal-organic frameworks (MOFs) and homogeneous catalysis due to its nitrogen and oxygen donor atoms.
• Material Science Research: Employed in the creation of organic electronic materials, such as charge-transport layers or light-emitting components.
• Fine Chemical Production: Acts as a versatile intermediate for synthesizing dyes, pigments, and other specialty chemicals requiring a functionalized quinoline structure.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including novel coupling and cyclization reactions.

Basic Information

Item	Detail
Product Name	6-tert-Butyl-4-Hydroxy- Quinoline-3-Carboxylic Acid
CAS No.	1065094-07-6
Molecular Formula	C₁₅H₁₇NO₃
Molecular Weight	259.30 g/mol
Synonyms	4-Hydroxy-6-tert-butylquinoline-3-carboxylic acid; 6-tert-Butyl-4-hydroxyquinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 6-(1,1-dimethylethyl)-4-hydroxy-; 6-(tert-Butyl)-4-hydroxyquinoline-3-carboxylic acid; TBHQCA; 4-Hydroxy-6-(tert-butyl)quinoline-3-carboxylic acid; 6-tert-Butyl-4-hydroxy-3-quinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 6-tert-Butyl-4-Hydroxy- Quinoline-3-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and oxidation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.