Description

8-Bromo-4-Chloro-5-Fluoro-Quinoline is a high-purity, multi-halogenated quinoline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated quinoline motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and antimicrobial agents.
• Agrochemical Research: Used in the development of new herbicides and fungicides where the quinoline scaffold provides biological activity.
• Material Science: Serves as a monomer or functional unit in the creation of organic semiconductors, luminescent materials, and metal-organic frameworks (MOFs).
• Chemical Biology: Employed as a molecular probe or tag due to its distinct halogen pattern for structure-activity relationship (SAR) studies.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for producing custom compounds for research purposes.

Basic Information

Product Name	8-Bromo-4-Chloro-5-Fluoro-Quinoline
CAS No.	1065093-11-9
Molecular Formula	C9H4BrClFN
Molecular Weight	260.49 g/mol
Synonyms	8-Bromo-4-chloro-5-fluoroquinoline; 5-Fluoro-8-bromo-4-chloroquinoline; Quinoline, 8-bromo-4-chloro-5-fluoro-; 4-Chloro-8-bromo-5-fluoroquinoline; 1065093-11-9 (CAS RN)
EINECS	Contact for details

Quality Control

Our 8-Bromo-4-Chloro-5-Fluoro-Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.