Description

4-Amino-7-Trifluoromethoxyquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinoline core substituted with amino and trifluoromethoxy functional groups. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorinated motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology, antiviral, and anti-inflammatory research.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Material Science: Serves as a precursor for the development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Synthesis: Acts as a versatile reagent for further functionalization, enabling the creation of more complex quinoline derivatives for various applications.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on the properties and reactivities of fluorinated heterocycles.

Basic Information

Product Name	4-Amino-7-Trifluoromethoxyquinoline
CAS No.	1065092-25-2
Molecular Formula	C₁₀H₇F₃N₂O
Molecular Weight	228.17 g/mol
Synonyms	7-(Trifluoromethoxy)quinolin-4-amine; 4-Amino-7-(trifluoromethoxy)quinoline; 4-Amino-7-trifluoromethoxy-quinoline; Quinoline, 4-amino-7-(trifluoromethoxy)-; 1065092-25-2; 4-Amino-7-trifluoromethoxy quinoline; 7-Trifluoromethoxy-4-aminoquinoline
EINECS	Contact for details

Quality Control

Our 4-Amino-7-Trifluoromethoxyquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.