Description

4-Amino-3-Bromo-5,8-Difluoroquinoline is a high-purity, multi-functional halogenated quinoline derivative, serving as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring strategically placed amino, bromo, and fluoro substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in developing fluorinated quinolone antibiotics and other bioactive molecules targeting specific enzymes or receptors.
• Agrochemical Research: Used to create new classes of fungicides, herbicides, and pesticides, where the fluorine atoms enhance biological activity, stability, and environmental persistence.
• Material Science: Serves as a monomer or functionalizing agent in the development of advanced organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Synthesis: Acts as a versatile scaffold for further functionalization via the reactive amino and bromo groups, enabling the creation of diverse chemical libraries for high-throughput screening.
• Ligand & Catalyst Development: Utilized in the design of novel chelating ligands for metal catalysts used in cross-coupling and other transition metal-catalyzed reactions.

Basic Information

Product Name	4-Amino-3-Bromo-5,8-Difluoroquinoline
CAS No.	1065088-54-1
Molecular Formula	C9H5BrF2N2
Molecular Weight	259.05 g/mol
Synonyms	3-Bromo-5,8-difluoroquinolin-4-amine; 5,8-Difluoro-3-bromoquinolin-4-amine; 4-Amino-3-bromo-5,8-difluoroquinoline; 4-Quinolinamine, 3-bromo-5,8-difluoro-; 1065088-54-1; 3-Bromo-5,8-difluoro-4-quinolinamine
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-3-Bromo-5,8-Difluoroquinoline is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA), including results for purity (HPLC), identity (NMR, IR), and impurity profiles, is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.