Description

4-Amino-3-Bromo-5,7-Difluoroquinoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique halogenated and aminated quinoline structure makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for creating complex molecules with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates, particularly for antimicrobial, anticancer, and anti-inflammatory applications.
• Agrochemical Research: Used to develop new generations of herbicides, fungicides, and pesticides, leveraging the bioactivity of the fluorinated quinoline scaffold.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce complex functionalities.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for metal catalysis and coordination chemistry.
• Fluorescent Probe Synthesis: Acts as a core structure for developing sensitive fluorescent dyes and sensors used in biochemical assays and diagnostics.

Basic Information

Product Name	4-Amino-3-Bromo-5,7-Difluoroquinoline
CAS No.	1065088-51-8
Molecular Formula	C9H5BrF2N2
Molecular Weight	259.05 g/mol
Synonyms	3-Bromo-5,7-difluoroquinolin-4-amine; 4-Amino-3-bromo-5,7-difluoroquinoline; 5,7-Difluoro-3-bromoquinolin-4-amine; Quinoline, 4-amino-3-bromo-5,7-difluoro-; 1065088-51-8; 3-Bromo-5,7-difluoro-4-quinolinamine
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Bromo-5,7-Difluoroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.