Description

4-Amino-3-Bromo-8-Trifluoromethylquinoline is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring amino, bromo, and trifluoromethyl substituents on the quinoline core, makes it a versatile precursor for constructing complex molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold in the synthesis of novel drug candidates, particularly for targets where the quinoline moiety and fluorine atoms can enhance bioavailability and binding affinity.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the bromine atom offers a handle for further functionalization to optimize biological activity.
• Material Science Precursor: Acts as a building block for creating specialized organic ligands, dyes, or fluorinated polymers with unique electronic or optical properties.
• Chemical Biology Probe: Employed in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create diverse compound libraries.
• Fluorine Chemistry: The trifluoromethyl group provides a source of fluorine for modulating lipophilicity, metabolic stability, and electronic characteristics in lead optimization.

Basic Information

Product Name	4-Amino-3-Bromo-8-Trifluoromethylquinoline
CAS No.	1065088-48-3
Molecular Formula	C10H6BrF3N2
Molecular Weight	291.07 g/mol
Synonyms	3-Bromo-4-amino-8-(trifluoromethyl)quinoline; 8-Trifluoromethyl-4-amino-3-bromoquinoline; 4-Amino-3-bromo-8-(trifluoromethyl)quinoline; Quinoline, 4-amino-3-bromo-8-(trifluoromethyl)-; 1065088-48-3
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Bromo-8-Trifluoromethylquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.