Description

4-Amino-3-Bromo-6-Fluoroquinoline is a high-purity, multi-functional quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique halogenated and aminated structure makes it an invaluable intermediate for constructing complex molecules with tailored biological and material properties. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotics and other bioactive heterocyclic compounds targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new-generation fungicides and herbicides, leveraging its halogenated quinoline core for enhanced activity.
• Material Science: Serves as a building block for organic light-emitting diodes (OLEDs) and other electronic materials due to its electron-rich, conjugated system.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex quinoline motifs into target molecules.
• Ligand and Catalyst Development: Utilized to create novel nitrogen-containing ligands for transition metal catalysis.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs and structure-activity relationship (SAR) studies in university and CRO laboratories.

Basic Information

Product Name	4-Amino-3-Bromo-6-Fluoroquinoline
CAS No.	1065088-21-2
Molecular Formula	C9H6BrFN2
Molecular Weight	241.06 g/mol
Synonyms	3-Bromo-6-fluoro-4-quinolinamine; 4-Quinolinamine, 3-bromo-6-fluoro-; 6-Fluoro-3-bromo-4-aminoquinoline; 4-Amino-3-bromo-6-fluoro-quinoline; 1065088-21-2; 3-Bromo-6-fluoroquinolin-4-amine; 4-Amino-3-bromo-6-fluoroquinoline
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Bromo-6-Fluoroquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a Certificate of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure it meets the stringent requirements for research and process development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.