Description

4-Amino-3-Bromo-6-Trifluoromethoxyquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated quinoline structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced biological activity and metabolic stability. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapies, particularly in oncology and anti-infective research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) for investigational new drugs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fluorinated Compound Synthesis: The trifluoromethoxy group makes it valuable for creating fluorinated analogs to improve drug potency, lipophilicity, and bioavailability.
• Agrochemical Development: Used in research for developing new generation herbicides and pesticides with the quinoline core.
• Organic Light-Emitting Diode (OLED) Materials: Potential use as an electron-transport or host material in the research of advanced optoelectronic devices.
• Ligand Synthesis for Catalysis: Can be modified to create novel nitrogen-donor ligands for transition metal catalysis.

Basic Information

Item	Details
Product Name	4-Amino-3-Bromo-6-Trifluoromethoxyquinoline
CAS No.	1065088-12-1
Molecular Formula	C₁₁H₆BrF₃N₂O
Molecular Weight	319.08 g/mol
Synonyms	3-Bromo-4-amino-6-(trifluoromethoxy)quinoline; 6-(Trifluoromethoxy)-3-bromoquinolin-4-amine; 4-Amino-3-bromo-6-(trifluoromethoxy)quinoline; 4-Quinolinamine, 3-bromo-6-(trifluoromethoxy)-; 3-Bromo-6-trifluoromethoxy-quinolin-4-ylamine
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Bromo-6-Trifluoromethoxyquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP principles and ISO 9001 standards ensures reliable supply for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under subdued lighting where practical.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.