Description

3-Bromo-4-Hydroxy-8-Trifluoromethoxyquinoline is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is critical for research and development in pharmaceutical and agrochemical discovery due to its unique halogenated and trifluoromethoxy-substituted quinoline scaffold. It is primarily utilized by medicinal chemists and process development scientists seeking to introduce complex molecular features into novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science: Acts as a building block for creating specialized organic ligands, catalysts, or functional monomers for advanced polymers.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms or protein-ligand interactions.
• Academic & Contract Research: Essential for fundamental research in organic chemistry and medicinal chemistry within universities and CROs (Contract Research Organizations).

Basic Information

Product Name	3-Bromo-4-Hydroxy-8-Trifluoromethoxyquinoline
CAS No.	1065087-93-5
Molecular Formula	C11H5BrF3NO2
Molecular Weight	320.06 g/mol
Synonyms	8-(Trifluoromethoxy)-3-bromo-4-hydroxyquinoline; 3-Bromo-4-hydroxy-8-(trifluoromethoxy)quinoline; 4-Hydroxy-3-bromo-8-trifluoromethoxyquinoline; Quinoline, 3-bromo-4-hydroxy-8-(trifluoromethoxy)-; 1065087-93-5; 3-Bromo-4-hydroxyquinolin-8-yl trifluoromethyl ether
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-4-Hydroxy-8-Trifluoromethoxyquinoline is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are supported by comprehensive Certificates of Analysis (COA) detailing specifications and test results. We adhere to cGMP (current Good Manufacturing Practice) guidelines for pharmaceutical intermediates, ensuring traceability and reliability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.