Description

3-Bromo-4-Hydroxy-7-Trifluoromethoxyquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and trifluoromethoxy-substituted quinoline structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting complex diseases. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate its distinct pharmacophore into new molecular entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds with quinoline-based scaffolds.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Agrochemical Development: Serves as a precursor in the creation of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoline core.
• Fluorine Chemistry: The trifluoromethoxy group makes it a valuable synthon for introducing fluorine atoms into target molecules to enhance metabolic stability, lipophilicity, and bioavailability.
• Material Science: Potential use in the development of organic electronic materials, ligands for catalysis, and specialty dyes or pigments.

Basic Information

Product Name	3-Bromo-4-Hydroxy-7-Trifluoromethoxyquinoline
CAS No.	1065087-90-2
Molecular Formula	C11H5BrF3NO2
Molecular Weight	320.06 g/mol
Synonyms	3-Bromo-4-hydroxy-7-(trifluoromethoxy)quinoline; 7-(Trifluoromethoxy)-3-bromo-4-quinolinol; 4-Quinolinol, 3-bromo-7-(trifluoromethoxy)-; 3-Bromo-4-hydroxy-7-trifluoromethoxy-quinoline; 1065087-90-2; 3-Br-4-OH-7-OCF3-quinoline
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Hydroxy-7-Trifluoromethoxyquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.