Description

3-Bromo-4-Hydroxy-6-Trifluoromethylquinoline is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is strategically important for its unique molecular architecture, combining a bromo-substituent for cross-coupling reactions, a phenolic hydroxyl group for further derivatization, and a trifluoromethyl group to impart desirable physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors, antimicrobial agents, and other biologically active quinoline derivatives.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the trifluoromethyl group can enhance bioavailability and stability.
• Material Science: Serves as a building block for advanced organic materials, including ligands for catalysis, organic semiconductors, and fluorescent dyes.
• Chemical Synthesis: The bromine atom facilitates versatile metal-catalyzed cross-coupling reactions (e.g., Suzuki, Heck), while the hydroxyl group allows for etherification or esterification.
• Academic & Contract Research: An essential reagent for medicinal chemistry programs and structure-activity relationship (SAR) studies in university and CRO laboratories.

Basic Information

Product Name	3-Bromo-4-Hydroxy-6-Trifluoromethylquinoline
CAS No.	1065087-84-4
Molecular Formula	C₁₀H₅BrF₃NO
Molecular Weight	292.06 g/mol
Synonyms	6-(Trifluoromethyl)-3-bromoquinolin-4-ol; 3-Bromo-4-hydroxy-6-(trifluoromethyl)quinoline; 4-Hydroxy-3-bromo-6-trifluoromethylquinoline; 3-Bromo-6-trifluoromethyl-4-quinolinol; Quinoline, 3-bromo-4-hydroxy-6-(trifluoromethyl)-; 1065087-84-4
EINECS	Contact for details

Quality Control

Our production of 3-Bromo-4-Hydroxy-6-Trifluoromethylquinoline adheres to stringent quality management protocols. Each batch is characterized and tested to ensure high chemical purity and lot-to-lot consistency, meeting the exacting standards required for research and scale-up activities. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.