Description

(S)-A-(Fmoc-n-Methylamino)Benzenebutanoic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected N-methylamino group. This compound is a critical chiral building block designed for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, high-quality intermediates for drug discovery and development programs.

Application

• Peptide Synthesis: A key chiral intermediate for the incorporation of N-methylated amino acid residues into peptide chains, enhancing metabolic stability and membrane permeability.
• Pharmaceutical Research: Used in the discovery and development of novel therapeutic peptides, peptidomimetics, and macrocyclic drugs.
• Combinatorial Chemistry: Serves as a specialized building block in the generation of diverse chemical libraries for high-throughput screening.
• Bioconjugation: The carboxylic acid moiety allows for conjugation to other molecules, carriers, or solid supports for various biochemical applications.
• API Intermediate: Employed in the synthetic pathway of active pharmaceutical ingredients (APIs) that contain modified amino acid structures.

Basic Information

Product Name	(S)-A-(Fmoc-n-Methylamino)Benzenebutanoic Acid
CAS No.	1065076-30-3
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	(S)-4-(Fmoc-N-methylamino)benzenebutanoic acid; (S)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)benzenebutanoic acid; Fmoc-N-Me-4-aminophenylbutyric acid; Fmoc-N-methyl-4-aminophenylbutyric acid; (S)-Fmoc-N-methyl-4-aminophenylbutanoic acid; Nα-Fmoc-Nα-methyl-4-aminophenylbutyric acid; Fmoc-Me-APBA
EINECS	Contact for details

Quality Control

Our (S)-A-(Fmoc-n-Methylamino)Benzenebutanoic Acid is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the exacting standards required for advanced research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.