Description

2-Chloro-1-(Ethylsulfonyl)-4-Fluorobenzene is a high-purity, multi-functional aromatic sulfone building block of significant importance in advanced organic synthesis. Its unique structure, featuring chloro, fluoro, and ethylsulfonyl substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine and sulfone groups enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and advanced electronic materials.
• Cross-Coupling Reactions: The chloro and fluoro substituents make it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl systems.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.

Basic Information

Product Name	2-Chloro-1-(Ethylsulfonyl)-4-Fluorobenzene
CAS No.	1062559-01-6
Molecular Formula	C8H8ClFO2S
Molecular Weight	222.66 g/mol
Synonyms	1-Chloro-2-(Ethylsulfonyl)-5-Fluorobenzene; 2-Chloro-1-(Ethylsulfonyl)-4-Fluorobenzene; 4-Fluoro-2-chloro-1-(ethylsulfonyl)benzene; 5-Fluoro-2-chlorophenyl Ethyl Sulfone; Ethyl 5-Fluoro-2-chlorophenyl Sulfone; Benzene, 2-chloro-1-(ethylsulfonyl)-4-fluoro-; 1062559-01-6
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-1-(Ethylsulfonyl)-4-Fluorobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA), including results from HPLC, GC, NMR, and mass spectrometry, is supplied with each shipment to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.