Description

3,9-Diazaspiro[5.5]Undecane-3-Carboxylic Acid, 8-Oxo-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and diaza structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) agents, receptor modulators, and other sophisticated small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities (NCEs).
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors targeting specific enzymatic pathways.
• Peptidomimetic Synthesis: The spirocyclic structure is valuable for creating conformationally restricted peptide analogs with enhanced metabolic stability.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological targets and pathways in vitro.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects under cGMP conditions.

Basic Information

Product Name	3,9-Diazaspiro[5.5]Undecane-3-Carboxylic Acid, 8-Oxo-, 1,1-Dimethylethyl Ester
CAS No.	1061731-86-9
Molecular Formula	C14H24N2O3
Molecular Weight	268.35 g/mol
Synonyms	tert-Butyl 8-oxo-3,9-diazaspiro[5.5]undecane-3-carboxylate; 3-(tert-Butoxycarbonyl)-3,9-diazaspiro[5.5]undecan-8-one; 3,9-Diazaspiro[5.5]undecane-3-carboxylic acid, 8-oxo-, 1,1-dimethylethyl ester; 8-Oxo-3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester; BOC-3,9-Diazaspiro[5.5]undecan-8-one; tert-Butyl 8-oxo-3,9-diazaspiro[5.5]undecane-3-carboxylate; Spirocyclic diaza intermediate 1061731-86-9
EINECS	Contact for details

Quality Control

Our production of 3,9-Diazaspiro[5.5]Undecane-3-Carboxylic Acid, 8-Oxo-, 1,1-Dimethylethyl Ester adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up applications. The material is manufactured under controlled conditions with purity typically exceeding 97% (by HPLC). Comprehensive analytical testing, including HPLC, GC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.