Description

2,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid, 2-(1-Methylethyl)-, 1,1-Dimethylethyl Ester is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and diaza structure. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as central nervous system (CNS) disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a key building block in the production route for potential APIs targeting neurological and psychiatric conditions.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structural features make it a candidate for incorporation into linker or ligand components of heterobifunctional degraders.
• Chemical Biology Probes: Utilized in the development of specialized molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Item	Detail
Product Name	2,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid, 2-(1-Methylethyl)-, 1,1-Dimethylethyl Ester
CAS No.	1061682-96-9
Molecular Formula	C16H28N2O2
Molecular Weight	280.41 g/mol
Synonyms	tert-Butyl 2-isopropyl-2,8-diazaspiro[4.5]decane-8-carboxylate; 2-Isopropyl-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 2,8-Diazaspiro[4.5]decane-8-carboxylic acid, 2-(1-methylethyl)-, 1,1-dimethylethyl ester; 2,8-Diazaspiro[4.5]decane-8-carboxylic acid, 2-isopropyl-, tert-butyl ester; 2-Isopropyl-2,8-diazaspiro[4.5]decane-8-carboxylate tert-butyl; 1061682-96-9; Boc-2-isopropyl-2,8-diazaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our 2,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid, 2-(1-Methylethyl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.