Description

7-Chloro-1,2,3,4-Tetrahydro-2,6-Naphthyridine is a high-purity, advanced pharmaceutical intermediate and heterocyclic building block of significant importance in modern organic synthesis. Its value lies in its fused bicyclic structure, which serves as a privileged scaffold for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. This compound is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing seeking to construct complex molecular architectures with precision.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting neurological disorders and cancer.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex heterocyclic compounds for agrochemicals and specialty materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and process scale-up for clinical trial materials.
• Academic Research: Utilized in universities and research institutes for methodological development in organic chemistry and pharmacology studies.

Basic Information

Product Name	7-Chloro-1,2,3,4-Tetrahydro-2,6-Naphthyridine
CAS No.	1060816-44-5
Molecular Formula	C8H9ClN2
Molecular Weight	168.62 g/mol
Synonyms	7-Chloro-1,2,3,4-tetrahydro-2,6-naphthyridine; 2,6-Naphthyridine, 7-chloro-1,2,3,4-tetrahydro-; 7-Chloro-3,4-dihydro-2,6-naphthyridine; 7-Chloro-1,2,3,4-tetrahydro-2,6-naphthyridine; 7-Chloro-2,3,4,5-tetrahydro-1,6-naphthyridine (tautomer); 7-Chloro-THN; 7-Cl-THN; 1060816-44-5
EINECS	Contact for details

Quality Control

Our 7-Chloro-1,2,3,4-Tetrahydro-2,6-Naphthyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.