Description

1-(4-Bromopyridin-2-Yl)-4-Methylpiperazine is a high-purity brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its versatile reactivity, where the bromine atom serves as a key handle for cross-coupling reactions, enabling the rapid construction of complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its piperazine-pyridine scaffold.
• Material Science Precursor: Serves as a monomer or ligand precursor for creating functional polymers, metal-organic frameworks (MOFs), or catalysts.
• Cross-Coupling Reactions: An essential substrate for Suzuki-Miyaura, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to form carbon-carbon and carbon-nitrogen bonds.
• Chemical Biology Probe Synthesis: Utilized to create tagged or modified molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	1-(4-Bromopyridin-2-Yl)-4-Methylpiperazine
CAS No.	1060812-92-1
Molecular Formula	C10H14BrN3
Molecular Weight	256.14 g/mol
Synonyms	4-Bromo-2-(4-methylpiperazin-1-yl)pyridine; 1-(4-Bromo-2-pyridinyl)-4-methylpiperazine; 4-Methyl-1-(4-bromopyridin-2-yl)piperazine; 2-(4-Methylpiperazin-1-yl)-4-bromopyridine; 4-Bromo-2-(4-methyl-1-piperazinyl)pyridine; N-(4-Bromopyridin-2-yl)-N'-methylpiperazine
EINECS	Contact for details

Quality Control

Our 1-(4-Bromopyridin-2-Yl)-4-Methylpiperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.