Description

[4-(Difluoromethoxy)Benzyl]Hydrazine Dihydrochloride is a high-purity, specialty organic intermediate of significant importance in advanced chemical synthesis. Its core value lies in its functionalized benzyl hydrazine structure, which serves as a critical building block for constructing complex nitrogen-containing heterocycles and active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for their synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging the difluoromethoxy group for enhanced biological activity and metabolic stability.
• Fine Chemical Building Block: Employed in organic synthesis for the construction of complex molecules, including heterocyclic compounds like pyrazoles, pyrazolines, and other nitrogen-based scaffolds.
• Research & Development: Serves as a valuable reagent in medicinal chemistry and process R&D for exploring new chemical entities and optimizing synthetic routes.
• Ligand and Catalyst Development: Potential use in the preparation of specialized ligands for catalysis or as a component in metal-organic frameworks (MOFs).

Basic Information

Product Name	[4-(Difluoromethoxy)Benzyl]Hydrazine Dihydrochloride
CAS No.	1059626-03-7
Molecular Formula	C8H10F2N2O • 2HCl
Molecular Weight	267.09 g/mol
Synonyms	4-(Difluoromethoxy)benzylhydrazine dihydrochloride; 1-[[4-(Difluoromethoxy)phenyl]methyl]hydrazine dihydrochloride; (4-(Difluoromethoxy)phenyl)methanamine, N-amino-, dihydrochloride; p-(Difluoromethoxy)benzyl hydrazine dihydrochloride; Hydrazine, [(4-(difluoromethoxy)phenyl)methyl]-, dihydrochloride
EINECS	Contact for details

Quality Control

Our [4-(Difluoromethoxy)Benzyl]Hydrazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.