Description

2-Chloro-6-(Trifluoromethyl)Quinoline-3-Carbaldehyde is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a reactive aldehyde group and a halogenated, fluorinated quinoline scaffold, enabling precise molecular construction. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used to construct advanced active ingredients for crop protection products, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a building block for developing organic semiconductors, liquid crystals, and fluorescent dyes due to its conjugated quinoline structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Cross-Coupling Reactions: The chloro substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Nucleophilic Addition & Condensation: The reactive aldehyde group is ideal for condensation reactions (e.g., with amines, hydrazines) and nucleophilic additions to form new C-C and C-N bonds.

Basic Information

Product Name	2-Chloro-6-(Trifluoromethyl)Quinoline-3-Carbaldehyde
CAS No.	1057667-20-5
Molecular Formula	C11H5ClF3NO
Molecular Weight	259.61 g/mol
Synonyms	2-Chloro-6-(trifluoromethyl)-3-quinolinecarboxaldehyde; 2-Chloro-6-(trifluoromethyl)quinoline-3-carboxaldehyde; 3-Quinolinecarboxaldehyde, 2-chloro-6-(trifluoromethyl)-; 2-Chloro-6-trifluoromethylquinoline-3-carbaldehyde; 6-Trifluoromethyl-2-chloroquinoline-3-carboxaldehyde; 2-Chloro-6-(trifluoromethyl)quinoline-3-carbaldehyde; 1057667-20-5
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(Trifluoromethyl)Quinoline-3-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong acids/bases and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.