Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[4-(2-Methylpropyl)Benzoyl]-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibacterial and anti-inflammatory drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel quinolone and fluoroquinolone-based active pharmaceutical ingredients (APIs).
• Antibacterial Drug Research: Serves as a core scaffold for developing new antibacterial agents targeting resistant bacterial strains.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of clinical trial materials and commercial APIs.
• Biochemical Research: Employed as a reference standard or inhibitor in enzymatic and receptor-binding studies.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary molecules for specialized therapeutic applications.

Basic Information

Item	Information
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[4-(2-Methylpropyl)Benzoyl]-1-Piperazinyl]-4-Oxo-
CAS No.	1054130-93-6
Molecular Formula	C27H28FN3O4
Molecular Weight	477.53 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-(4-(4-isobutyrylbenzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(4-(2-methylpropyl)benzoyl)-1-piperazinyl)-3-quinolinecarboxylic acid; 7-[4-[4-(Isobutyryl)benzoyl]-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; GSK-1 Intermediate; Fluoroquinolone Derivative Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.