Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-(2,4,6-Trimethylbenzoyl)-1-Piperazinyl]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel fluoroquinolone antibiotics, offering a key building block for research and development in antimicrobial therapies. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and new drug discovery.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a core structural component in the synthesis of next-generation antibacterial agents.
• Pharmaceutical Research & Development: Used in the discovery and optimization of new drug candidates targeting bacterial infections.
• Process Chemistry & Scale-Up: Employed in the development of robust and efficient commercial-scale manufacturing routes for active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Studies: Utilized to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of quinolone-based drugs.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-(2,4,6-Trimethylbenzoyl)-1-Piperazinyl]-
CAS No.	1054130-38-9
Molecular Formula	C27H26FN3O4
Molecular Weight	475.51 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(2,4,6-trimethylbenzoyl)piperazin-1-yl]quinoline-3-carboxylic acid; 7-[4-(2,4,6-Trimethylbenzoyl)-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; Garenoxacin Intermediate; Garenoxacin Quinoline Core; AM-1155 Intermediate; T-3811 Intermediate; OPC-17116 Intermediate; 1-Cyclopropyl-6-fluoro-7-(4-mesitylcarbonylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We adhere to cGMP principles where applicable to ensure supply consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.