Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-(1-Oxo-2-Phenoxybutyl)-1-Piperazinyl]- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research importance. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering critical structural complexity for targeted therapeutic activity. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical synthesis specialists engaged in cutting-edge antimicrobial drug discovery and production.

Application

• Pharmaceutical Intermediate: Core building block for the synthesis of next-generation fluoroquinolone antibiotic candidates.
• Antimicrobial Research: Used in medicinal chemistry programs to develop new antibacterial agents with improved potency and spectrum of activity.
• API (Active Pharmaceutical Ingredient) Synthesis: A critical intermediate in the multi-step manufacturing process of complex antibiotic APIs.
• Process Chemistry & Scale-Up: Serves as a reference standard and starting material for process optimization and kilogram-scale production.
• Biochemical Research: Utilized in studies investigating bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.
• Fine Chemical Synthesis: Employed in the construction of complex heterocyclic systems for various specialty chemical applications.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-(1-Oxo-2-Phenoxybutyl)-1-Piperazinyl]-
CAS No.	1054130-23-2
Molecular Formula	C27H28FN3O5
Molecular Weight	493.53 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxo-2-phenoxybutyl)-1-piperazinyl]-3-quinolinecarboxylic acid; 7-(4-(1-Oxo-2-phenoxybutyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771 Intermediate; Advanced Fluoroquinolone Intermediate; Garenoxacin-related intermediate; 1-Cyclopropyl-6-fluoro-7-[4-(1-oxo-2-phenoxybutyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent pharmaceutical-grade quality standards. Every batch is subjected to comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We operate under a cGMP-compliant quality management system to support our clients' regulatory filings and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.