Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(2,3-Dimethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering a critical building block for medicinal chemistry and active pharmaceutical ingredient (API) manufacturing. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global life sciences sector.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of next-generation fluoroquinolone antibiotic candidates.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and the discovery of new antibacterial agents.
• Active Pharmaceutical Ingredient (API) Development: Integrated into the synthesis pathway for pilot-scale and commercial-scale API production.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and process development projects.
• Biochemical Research: Employed in studies targeting bacterial DNA gyrase and topoisomerase IV enzymes.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory filings.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(2,3-Dimethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054110-92-7
Molecular Formula	C26H26FN3O5
Molecular Weight	479.50 g/mol
Synonyms	1-Cyclopropyl-7-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(2,3-dimethoxybenzoyl)-1-piperazinyl)-3-quinolinecarboxylic Acid; Fluoroquinolone Intermediate; GSK2140944 Intermediate; Besifloxacin Related Compound; Advanced Fluoroquinolone Building Block
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.