Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(4-Ethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. It is essential for manufacturers and R&D laboratories in the pharmaceutical and fine chemical sectors requiring precise, reliable, and scalable synthetic components.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel fluoroquinolone antibiotics and other therapeutic agents.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new drug candidates targeting bacterial infections.
• Chemical Synthesis Research: Serves as a sophisticated substrate in organic and medicinal chemistry for studying structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Employed in optimizing and scaling manufacturing routes for complex molecules in pilot plants and commercial production.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) offering specialized synthesis services.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(4-Ethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054110-71-2
Molecular Formula	C26H26FN3O4
Molecular Weight	463.50 g/mol
Synonyms	1-Cyclopropyl-7-[4-(4-ethoxybenzoyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-(4-ethoxybenzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771 Intermediate; NXL 101 Intermediate; Zabofloxacin Intermediate; DW-224a Intermediate; (1-Cyclopropyl-6-fluoro-7-(4-(4-ethoxybenzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid)
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting specifications for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to support regulatory filings (e.g., DMF, CMC sections).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., nitrogen) when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.